Micky van de Ven Double Ends Everton's Run at Brand New Home Ground
The Dutch defender emerged as the first backline player to score two goals in a English top-flight match for Spurs since Jan Vertonghen in spring 2013.
Key points
The Spurs defender nods into the net two times in opening period
The home side's Jake O'Brien has goal disallowed after VAR review
Pape Matar Sarr nets third in 89th minute
This loss is Everton's first at Hill Dickinson Stadium
The Tottenham defender found the net twice as Tottenham prolonged their unbeaten run in away games in the top division and handed the Toffees their first defeat at their new home.
Everton were unbeaten in their last five matches at their new ground at the dockside location, having left their historic home behind after 133 years at the conclusion of last season.
But Tottenham's leader the Dutchman struck on two occasions from set-pieces in the opening 45 minutes to place their impressive record at jeopardy, and they were failed to mount a comeback before the midfielder - assisted by former Toffees attacker Richarlison - nodded in a final goal to seal the victory.
The Everton defender believed he had equalized the tally a short while after the defender's first goal, directing a powerful header past the Spurs keeper from an set-piece.
The Portuguese striker, in the meantime, missed a handful of opportunities, while Vicario made a succession of excellent stops to guarantee Tottenham went five matches on the road without defeat in the English top flight.
But the VAR intervened, instructing Craig Pawson to review the goal on the screen and the official decided that the winger and the attacker were in an illegal position and had impeded with the Spurs keeper.
This victory moves Thomas Frank's team up to third in the division, five points off north London rivals and table-toppers Arsenal.
Everton remain 14th and sit six points ahead of the relegation zone.
Tottenham analysis: Van de Ven fulfils duties at each end of the field
After a drab weekday performance in the European competition against the French side, where they managed a only two shots on target, the manager chose the French striker in attack instead of ex-Everton forward Richarlison.
The new arrival was unable to influence the game before being replaced for Richarlison after 60 minutes on the field, but it turns out he wasn't needed in the final outcome.
Centre-back Van de Ven converted into an attacking force to be reckoned with.
Tottenham's opening strike came from a cleverly executed set-piece play, with Rodrigo Bentancur heading the ball toward the six-yard box for an free Van de Ven to head home.
And Ven de Ven - filling in as skipper in the Argentine's unavailability - notched his second in added time as he rose above Jordan Pickford to head home.
Van de Ven was equally impressive in defence, combining well with his defensive colleague as the pair dealt excellently with the 34 crosses thrown their way by the opposition.
Toffees breakdown: Everton missing finishing touch
The club's new home had been a fortress, but it seems the novelty may have worn off slightly and fans headed to the gates after Sarr's third for Spurs.
The break in Everton's unbeaten home run will not be a major concern for the manager, but their attacking woes will be.
The forward and the other striker - the Everton's two recognised strikers - had netted only one league goal combined before the weekend's outing.
And they were unable to add to that miserable record on a damp and dreary evening on in Liverpool.
Beto's performance was epitomized when he chose to bicycle-kick a golden opportunity from close range, despite having room and time to reposition for a more conventional shot that would have challenged Vicario.
Barry, too, failed to influence the game after coming on for the starter in the 65th minute.
It wasn't for a lack of opportunity. The majority of Everton's offensive moves came through Grealish and the forward, who relentlessly delivered dangerous balls into the Tottenham penalty area.
What next for these two sides?
Everton: Moyes' men head to the Stadium of Light in the top flight on Monday, 3 November at 8 PM.
Spurs: The London club go to St James' Park on Wednesday, 29 October for their fourth-round League Cup match against Newcastle.